Endocrine Abstracts

Various alterations of the cyclic AMP (cAMP) signalling cascade has been observed in adrenocortical tumors. Changes of the PKA regulatory subunits expression in tumors may positively or negatively regulate proliferation. 8CL-cAMP, a site selective cAMP analogue, induces growth inhibition in a variety of human cancer cell lines. The aim of the study was to determine if 8CL-cAMP acts on adrenocortical carcinoma H295R cell growth.We have determined the invo...

Adrenocortical tumor (ACT) is a rare, heterogeneous malignancy whose pathogenesis is unclear. The oncoprotein PTHrP, found in many common tumors, can regulate their growth in an autocrine/paracrine fashion through the receptor PTH-R1. Little is known about the role of PTHrP in ACT. We monitored the synthesis of PTHrP and PTH-R1 in a series of 25 ACT: 12 adrenocortical carcinoma (ACC), 13 adrenocortical adenoma (ACA), and investigated the effects of PTHrP (1–34) on H295R c...